abstract：:The relationship between malignant tumors and blood coagulation disorders is generally well known. The authors studied blood coagulation in patients with colorectal cancer and evaluated some prothrombotic markers. The authors analyzed by latex-aglutination method, ProC Global test, Asserachrom PAI-1 test and Enzygnost...

journal_title：Neoplasma

authors： Mytnik M,Stasko J

更新日期：2011-01-01 00:00:00

abstract：:Multiple myeloma (MM) is a hematological malignancy caused by clonal proliferation of malignant plasma cells (PC). The aim of the work is to determine prognostic significance of morphological subtypes of PC in relation to overall treatment response, long-term survival and other conventional prognostic parameters. One ...

journal_title：Neoplasma

authors： Al-Sahmani M,Trnavska I,Sevcikova S,Antosova M,Antosova L,Kissova J,Adam Z,Pour L,Nemec P,Greslikova H,Krejci M,Zahradova L,Bulikova A,Penka M,Hajek R

更新日期：2011-01-01 00:00:00

abstract：:The present study was carried out to investigate the synergistic apoptotic potential of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma (MM) cell line U266 , in vitro. U266 cells were cultured with MGN-3 (50 or 100μg/ml) and curcumin (2.5-10μM) for 3 days. The effects of MGN-3 ...

journal_title：Neoplasma

authors： Ghoneum M,Gollapudi S

更新日期：2011-01-01 00:00:00

abstract：:The present study was undertaken to provide complementary information on heterochromatin condensation in central and peripheral nuclear regions during maturation of human leukemic lymphocytes using simple image processing and DNA image densitometry at the single cell level. Such approach indicated that the heterochrom...

journal_title：Neoplasma

authors： Smetana K,Karhan J,Trneny M

更新日期：2011-01-01 00:00:00

abstract：:CD147, a widely expressed cell surface glycoprotein in cancer, is associated with tumor invasiveness and chemotherapy resistance. Recently, CD147 is also regarded as a potential therapeutic target for cancer therapy. The aim of the study was to investigate CD147 expression in non-small cell lung cancer (NSCLC), and ev...

journal_title：Neoplasma

authors： Zeng HZ,Qu YQ,Liang AB,Deng AM,Zhang WJ,Xiu B,Wang H,Wang H

更新日期：2011-01-01 00:00:00

abstract：:Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing t...

journal_title：Neoplasma

authors： Halamkova J,Kiss I,Pavlovsky Z,Tomasek J,Jarkovsky J,Cech Z,Tucek S,Hanakova L,Moulis M,Zavrelova J,Man M,Benda P,Robek O,Kala Z,Penka M

更新日期：2011-01-01 00:00:00

abstract：UNLABELLED:Breast cancer is one of the most common cancer affecting women and the recent research is focused on identifying new genetic and epigenetic prognostic and predictive factors. Glutathione S-transferase P1 (GSTP1) is abiotransformation enzyme expressed in normal breast epithelial cells which can be epigenetica...

journal_title：Neoplasma

authors： Lasabova Z,Tilandyova P,Kajo K,Zubor P,Burjanivova T,Danko J,Plank L

更新日期：2010-01-01 00:00:00

abstract：:The aim of this work is to examine the influence of the dose optimization procedure on the value of radiation doses in organs of risk and to compare value of doses measured in healthy tissues according to chosen different PDR brachytherapy (PDRBT) and HDR brachytherapy (HDRBT) fractionation schedule. Fifty one patient...

journal_title：Neoplasma

authors： Skowronek J,Zwierzchowski G,Piotrowski T,Milecki P

更新日期：2010-01-01 00:00:00

abstract：:Hypoxia is one of the basic characteristics of the colorectal cancer and HIF1 plays a central role in tumor hypoxia adaptation and controls the expression of a variety of genes. But it had not reached a comprehensive understanding of them in colorectal cancer in hypoxia. This study silenced HIF1-alpha, which is the re...

journal_title：Neoplasma

authors： Wu XY,Fu ZX,Wang XH,Shen W

更新日期：2010-01-01 00:00:00

abstract：UNLABELLED:The study was aimed at detecting the expression of a newly found oncogene, astrocyte elevated gene-1 (AEG-1), in renal cell carcinoma (RCC) and its correlation with histopathologic features and the survival of patients. Real-time reverse transcription-PCR and Western blot showed markedly higher expression of...

journal_title：Neoplasma

authors： Chen W,Ke Z,Shi H,Yang S,Wang L

更新日期：2010-01-01 00:00:00

abstract：:Dendritic cells are able to induce anti-tumor immune responses by presenting tumor-specific antigens to T-lymphocytes. Various tumor-associated antigens have been studied in multiple myeloma in an effort to find a strong antigen capable of generating clinically meaningful responses in vaccinated patients. The aim of o...

journal_title：Neoplasma

authors： Ocadlikova D,Kryukov F,Mollova K,Kovarova L,Buresdova I,Matejkova E,Penka M,Buchler T,Hajek R,Michalek J

更新日期：2010-01-01 00:00:00

abstract：:The results of treatment of acute promyelocytic leukemia, when combination ATRA + chemotherapy is used in induction and maintainance therapy and risk adapted strategy applied in consolidation, improved at present time. Enhanced supportive therapy also contribute to improved outcome of APL patients. 3 - year relapse fr...

journal_title：Neoplasma

authors： Oravcova I,Czako B,Demeckova E,Demitrovicova L,Greksak R,Kotoucek P,Mego M,Mikuskova E,Richterova K,Al Sabti F,Mistrik M

更新日期：2010-01-01 00:00:00

abstract：UNLABELLED:Oncolytic viruses are examined to serve as anticancer therapeutics. It is expected that in addition to direct oncolytic effect their action will also help eliciting a solid antitumor immunity. In presented series of experiments we have employed two HPV16-transformed mouse (strain C57/B6) cell lines, TC-1 and...

journal_title：Neoplasma

authors： Figova K,Sobotkova E,Duskova M,Ludvikova V,Vonka V,Eckschlager T

更新日期：2010-01-01 00:00:00

abstract：:General anaesthesia is rarely applied during fractionated radiotherapy with the exception of unco-operative patients. We performed a retrospective study to inform our current practice in anaesthesia procedures for radiotherapy application in children, brachytherapy and intraoperative radiation. The records of anaesthe...

journal_title：Neoplasma

authors： Wojcieszek E,Rembielak A,Bialas B,Wojcieszek A

更新日期：2010-01-01 00:00:00

abstract：:Heat Shock proteins 70 (Hsp70) is a family of highly conserved molecules that maintain the function of crucial cellular pathways during stress. Hsp70 derived from tumor cells is bound with tumor antigenic peptides from the diverse antigen cytosolic pool. Tumor-derived Hsp70 preparations after ex vivo administration pe...

journal_title：Neoplasma

authors： Kumar S,Deepak P,Acharya A

更新日期：2009-01-01 00:00:00

abstract：:Cancer diagnosis and treatment often produce psychologic stresses resulting from the actual symptoms of the disease, as well as from perceptions of the disease and its stigma. Depression is seen in many cancer patients. Depression occurs in approximately 25% of palliative care patients. It is widely recognised by clin...

journal_title：Neoplasma

authors： Slovacek L,Slovackova B,Slanska I,Priester P,Petera J,Kopecky J,Vanaskova J

更新日期：2009-01-01 00:00:00

abstract：:Human leukocyte antigen - G (HLA-G) is a non-classical HLA class I antigen with restricted distribution in normal tissues. Ectopic HLA-G expression observed at some pathological circumstances as malignant transformation might be triggered by epigenetic modifications such as DNA demethylation. Recently it was demonstra...

journal_title：Neoplasma

authors： Polakova K,Bandzuchova E,Sabty FA,Mistrik M,Demitrovicova L,Russ G

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:Results of radiochemotherapy in 50 patients with squamous cell carcinoma of the anal canal, treated with radical radiochemotherapy between January 2003 and September 2007, at the Institute of Oncology Ljubljana are presented. The treatment schedule consisted of 3-D conformal external beam radiotherapy (45 Gy...

journal_title：Neoplasma

authors： Oblak I,Petric P,Anderluh F,Velenik V,Hudej R,Fras AP

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:BioBran, enzymatically modified arabinoxylan from rice bran was tested for its possible effects on in vitro maturation of human dendritic cells (DC). Immature DC (iDC) derived from plastic-adhered, IL-4 and GM-CSF treated peripheral monocytes (Mo) were further cultured with cytokine maturation mix 1 (CMM1; T...

journal_title：Neoplasma

authors： Cholujova D,Jakubikova J,Sedlak J

更新日期：2009-01-01 00:00:00

abstract：:We processed data of 79 patients (pts) with malignant lymphoma from the National Registry of haematopoietic stem cell transplants conducted between 1997 and 2006. The haematopoietic stem cell donor in 48 pts was an HLA matched relative, and in 30 pts an unrelated volunteer. Sixty (77%) pts were transplanted with reduc...

journal_title：Neoplasma

authors： Valkova V,Benesova K,Vitek A,Faber E,Mayer J,Zak P,Trneny M

更新日期：2009-01-01 00:00:00

abstract：:Cancer cells share numerous characteristics with pluripotent stem cells which develop normally, contributing to the tumor cell plasticity. So we investigated the effect of human embryonic germ cells (hEGCs) on SKOV3 cells. We examined the efficacy of hEGCs through coculturing SKOV3 with hEGCs, detecting tunel apoptosi...

journal_title：Neoplasma

authors： Song X,Kong B,Li D,Yang Q

更新日期：2009-01-01 00:00:00

abstract：:Due to problems with identification and an incomplete understanding on the gastrointestinal stromal tumors (GIST) before 2001, there has been a lack of comprehensive long-term population-based studies on GIST epidemiology at present date. We used data from the online registry of Czech and Slovak GIST patients (http://...

journal_title：Neoplasma

authors： Brabec P,Sufliarsky J,Linke Z,Plank L,Mrhalova M,Pavlik T,Klimes D,Gregor J

更新日期：2009-01-01 00:00:00

abstract：:The determination of patient's resistance to a particular drug contributes to more efficient therapeutical approach. The aim of this study was to evaluate if the responsiveness of Chronic Myeloid Leukemia (CML) patients to Imatinib therapy was predictable from WT1 gene expression in peripheral blood leukocytes. To exa...

journal_title：Neoplasma

authors： Otahalova E,Ullmannova-Benson V,Klamova H,Haskovec C

更新日期：2009-01-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is a diverse group of cancers that are frequently aggressive in their biologic behavior. Inactivation of tumor suppressor gene (TSG) is one of the most critical steps leading to HNSCC. Loss of heterozygosity analysis is very sensitive method for the detection of frequent a...

journal_title：Neoplasma

authors： Cetin E,Cengiz B,Gunduz E,Gunduz M,Nagatsuka H,Bekir-Beder L,Fukushima K,Pehlivan D,N MO,Nishizaki K,Shimizu K,Nagai N

更新日期：2008-01-01 00:00:00

abstract：:Photodynamic therapy (PDT) has been developed in recent years as a new modality for the treatment of various neoplastic and non-neoplastic lesions. Although the method of combining light with photosensitizers for treatment has been around for a century, further understanding has been evolved over the past decades. The...

journal_title：Neoplasma

authors： Stukavec J,Horak L,Duchac V,Jirasek T,Rakusan J,Karaskova M,Pouckova P

更新日期：2008-01-01 00:00:00

abstract：:Immunohistochemistry (IE) and polymerase chain reaction (PCR) are tools enabling to find small number of tumor cells in lymph nodes (LNs) or peripheral blood. Perhaps these methods will allow early detection of cell dissemination and refine risk group within papillary thyroid cancer (PTC) that might benefit from more ...

journal_title：Neoplasma

authors： Kaczka K,Jakubiak-Wielganowicz M,Zawlik I,Ziolkowski R,Kuzdak K,Pomorski L

更新日期：2008-01-01 00:00:00

abstract：:MHC class I chain-related molecule A (MICA) is one of the major ligands for activating immune-receptor NKG2D which is expressed on NK cells and cytotoxic T lymphocytes. The release and sustained expression of MICA protein can impair NKG2D-mediated cytotoxic activity by reducing NKG2D receptor on immune effector cells....

journal_title：Neoplasma

authors： Lu SM,Xiao P,Xue L,Che LH,Yang P,Li Y,Qiao H

更新日期：2008-01-01 00:00:00

abstract：:The reliability of a particular in vitro parameter as potential prognostic biomarker of individual radiosensitivity is still discussed. Therefore, several in vitro radiation-induced cellular endpoints including initial, oxidative and residual DNA damage and the rate of DNA repair were assessed in peripheral blood lymp...

journal_title：Neoplasma

authors： Gabelova A,Farkasova T,Gurska S,Machackova Z,Lukacko P,Witkovsky V

更新日期：2008-01-01 00:00:00

abstract：:Interphase fluorescence in situ hybridization was used to detect common deletions in B-CLL patients as well as trisomy 12 and aberrations of IgH gene complex at 14q32.33 where we evaluated not only translocation-like signal pattern but also deletions. 120 (82%) patients showed genetic changes - del(13)(q14) 95 (62%), ...

journal_title：Neoplasma

authors： Berkova A,Pavlistova L,Babicka L,Houskova L,Tajtlova J,Balazi P,Cmunt E,Schwarz J,Karban J,Trneny M,Brezinova J,Zemanova Z,Michalova K

更新日期：2008-01-01 00:00:00

abstract：:KLF6 is a key cell cycle regulator that is downregulated in several kinds of human cancers, including gastric cancer. The IVS1 -27G/A polymorphism of KLF6 has been investigated, which can influence susceptibility to gastric cancer and disease outcome. In order to investigate whether the IVS1 -27G/A polymorphism of KLF...

journal_title：Neoplasma

authors： Cho YG,Lee HS,Song JH,Kim CJ,Park YK,Nam SW,Yoo NJ,Lee JY,Park WS

更新日期：2008-01-01 00:00:00

abstract：:Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine ...

journal_title：Neoplasma

authors： Zang S,Ji Ch,Qu X,Dong X,Ma D,Ye J,Ma R,Dai J,Guo D

更新日期：2007-01-01 00:00:00

abstract：:The work is aimed at the occurrence of secondary malignancies after therapy for primary testicular tumors. The target of the work was determination of the number and type of secondary tumors, their effect on the survival and comparison of relative risk of the origination of secondary tumors depending on particular tre...

journal_title：Neoplasma

authors： Siffnerova H,Kralova D

更新日期：2007-01-01 00:00:00

abstract：:Eucalyptol, carvacrol and thymol represent components of plant essential oils characterized by a wide range of biological effects toward microorganisms, fungi, insects, etc. However, till now only a few investigations have been carried out to study the effects of essential oils and their components on human cells cult...

journal_title：Neoplasma

authors： Horvathova E,Turcaniova V,Slamenova D

更新日期：2007-01-01 00:00:00

abstract：:Sentinel node biopsy becomes a standard diagnostic and therapeutic tool in breast cancer in certain indications, while in other indications its validity is still reviewed. The authors present their experience with this method. In the years 2000-2006 700 patients underwent surgery. 704 sentinel node biopsies were perfo...

journal_title：Neoplasma

authors： Fait V,Chrenko V

更新日期：2007-01-01 00:00:00

abstract：:Recent studies have provided strong evidence for potential beneficial effects of flavonoids in chemoprevention or in combination with chemotherapeutics in tumor cells treatment. The aim of this work was to compare the antioxidant properties of four flavonoids with emphasis on association of these antioxidant propertie...

journal_title：Neoplasma

authors： Nadova S,Miadokova E,Cipak L

更新日期：2007-01-01 00:00:00

abstract：:In this work we tried to estimate the role of mitochondria in the ability of cells of two: melanotic and amelanotic transplantable melanoma lines to undergo spontaneous and camptothecin-induced apoptosis. We measured mitochondrial transmembrane potential (DeltaPsi) changes during culture without (spontaneous apoptosis...

journal_title：Neoplasma

authors： Cichorek M,Kozłowska K,Bryl E

更新日期：2007-01-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited cancer predisposition syndrome due to germline mutations in the VHL tumor suppressor gene which is associated with virtually complete penetrance. The VHL syndrome has a highly variable phenotypic expressivity including retinal and CNS haemangioblasto...

journal_title：Neoplasma

authors： Stanojevic BR,Lohse P,Neskovic GG,Damjanovic SM,Novkovic TB,Jovanovic-Cupic SP,Dimitrijević BB

更新日期：2007-01-01 00:00:00

abstract：:Protein p53 is the tumor suppressor involved in cell cycle control and apoptosis. As a transcription factor p53 controls many cell processes and helps in prevention of cancer development. The p53 gene is polymorphic. Polymorphisms can affect the important regions involved in protein tumor suppressor activity. The well...

journal_title：Neoplasma

authors： Franeková M,Zúbor P,Stanclová A,Dussan CA,Bohusová T,Galo S,Dobrota D,Kajo K,Péc M,Racay P

更新日期：2007-01-01 00:00:00

abstract：:Positron emission tomography (PET) is a new diagnostic method recently widely used in oncology. It is applied to distinguish benign and malign tumors, to diagnose relaps or posttherapeutic changes. PET is also complementary method to the standard used methods such as CT or NMR. Now it is used even as the predict facto...

journal_title：Neoplasma

authors： Dolezelová H,Slampa P

更新日期：2007-01-01 00:00:00

abstract：:The role of heat shock protein 70 (HSP70) expression has been investigated in various types of tumors. There are only little and controversial data about its clinical relevance in colorectal carcinoma, one of the most common carcinomas observed in humans. In this study we investigated expression of HSP70 in human colo...

journal_title：Neoplasma

authors： Milićević ZT,Petković MZ,Drndarević NC,Pavlović MD,Todorović VN

更新日期：2007-01-01 00:00:00